Tesamorelin (10mg)
Rated 4.8 out of 5
$137.97
A synthetic analog of growth hormone-releasing hormone (GHRH), Tesamorelin stimulates endogenous growth hormone production and release from the anterior pituitary gland. Extensive research has examined its potential to improve metabolic health, reduce visceral adipose tissue, and support cognitive function, with study populations including individuals with HIV-associated lipodystrophy and age-related cognitive decline. Requires reconstitution before use.
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Research Use Only: All materials are supplied exclusively for in vitro research and laboratory work by qualified professionals and are not marketed as drugs, supplements, or medical products.
A synthetic analog of growth hormone-releasing hormone (GHRH), Tesamorelin stimulates endogenous growth hormone production and release from the anterior pituitary gland. Extensive research has examined its potential to improve metabolic health, reduce visceral adipose tissue, and support cognitive function, with study populations including individuals with HIV-associated lipodystrophy and age-related cognitive decline. Requires reconstitution before use.
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This material is sold strictly for qualified laboratory and in vitro research. It is not a drug, food, dietary supplement, or cosmetic and is not approved for human or animal use. Any attempt to ingest, inject, or otherwise introduce this material into the body is prohibited. Misuse, misbranding, or reselling this material for non-research purposes is strictly forbidden. Information provided on this site is for educational purposes only. The statements made within this website have not been evaluated by the U.S. Food and Drug Administration (FDA). Neither the statements nor the products offered by this company are intended to diagnose, treat, cure, or prevent any disease.
Table of Contents
1. Characteristics
2. How does Tesamorelin work?
Tesamorelin is a synthetic GHRH analog whose primary mechanism involves binding to and activating the growth hormone-releasing hormone receptor (GHRHR) in the anterior pituitary gland, stimulating pulsatile endogenous growth hormone (GH) release and subsequent insulin-like growth factor-1 (IGF-1) production in the liver and peripheral tissues.
3. Research
- Visceral Adipose Tissue (VAT) Reduction: Clinical studies demonstrate significant VAT reduction in individuals with HIV-associated lipodystrophy and obese populations without HIV, accompanied by improvements in metabolic health markers.
- Insulin Sensitivity: Evidence indicates tesamorelin may improve insulin sensitivity in HIV-associated lipodystrophy and non-HIV obese populations.
- Cognitive Function: Preliminary findings in older adults with mild cognitive impairment suggest possible improvements in executive function, attention, and memory.
- Muscle Mass and Strength: Research points to increases in muscle mass and strength in older adults and individuals with HIV-associated lipodystrophy.
- Bone Health: Studies have observed improvements in bone mineral density following tesamorelin treatment in HIV-associated lipodystrophy populations.
4. Side Effects
Commonly reported effects include injection site reactions, edema, arthralgia, and hypersensitivity reactions. Less frequent occurrences include headache, dizziness, and gastrointestinal disturbances. Carpal tunnel syndrome and increased malignancy risk have been noted in rare cases.
5. Summary
By stimulating endogenous GH release and subsequent IGF-1 production, Tesamorelin has demonstrated meaningful effects on VAT reduction, insulin sensitivity, cognitive function, muscle mass, and bone health across metabolic and aging-related research contexts. Its potential to elucidate the relationship between growth hormone, metabolism, and cognition positions it as a valuable tool for investigating novel therapeutic strategies.
6. References
- 1. Dhillon S. Tesamorelin: a review of its use in the management of HIV-associated lipodystrophy. Drugs, 2011. PubMed 21668043
- 2. Spooner LM, Olin JL. Tesamorelin: a growth hormone-releasing factor analogue for HIV-associated lipodystrophy. Ann Pharmacother, 2012. PubMed 22298602
- 3. Clinical Review Report: Tesamorelin (Egrifta). Canadian Agency for Drugs and Technologies in Health, 2016. PubMed 30920787
- 4. Pharmacoeconomic Review Report: Tesamorelin (Egrifta). Canadian Agency for Drugs and Technologies in Health, 2016. PubMed 30896905
- 5. Wang Y, Tomlinson B. Tesamorelin, a human growth hormone releasing factor analogue. Expert Opinion on Investigational Drugs, 2009. PubMed 19243281
7. Research use
All products on this site are intended exclusively for research and development use. Products are not for human or animal consumption of any kind.
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