Thymosin Beta 4 (TB500) (10mg)
Rated 4.8 out of 5
$137.99
Thymosin Beta-4 (TB-500) is a naturally occurring peptide extensively studied for its therapeutic potential across dermatology, ophthalmology, and regenerative medicine. Research points to its capacity to promote wound healing, modulate inflammation, and stimulate hair growth. Requires reconstitution before use.
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TB-500 — research caution
TB-500 (Thymosin Beta-4 fragment) promotes new blood vessel formation and cell migration—pathways studied in tissue-repair research. In animal studies it has been associated with faster growth of dormant tumors and changes in immune response. This material is not suitable for research when active or dormant cancer has not been reasonably ruled out. It must not replace proper medical or clinical cancer screening.
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Research Use Only: All materials are supplied exclusively for in vitro research and laboratory work by qualified professionals and are not marketed as drugs, supplements, or medical products.
Thymosin Beta-4 (TB-500) is a naturally occurring peptide extensively studied for its therapeutic potential across dermatology, ophthalmology, and regenerative medicine. Research points to its capacity to promote wound healing, modulate inflammation, and stimulate hair growth. Requires reconstitution before use.
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This material is sold strictly for qualified laboratory and in vitro research. It is not a drug, food, dietary supplement, or cosmetic and is not approved for human or animal use. Any attempt to ingest, inject, or otherwise introduce this material into the body is prohibited. Misuse, misbranding, or reselling this material for non-research purposes is strictly forbidden. Information provided on this site is for educational purposes only. The statements made within this website have not been evaluated by the U.S. Food and Drug Administration (FDA). Neither the statements nor the products offered by this company are intended to diagnose, treat, cure, or prevent any disease.
Table of Contents
1. Characteristics
2. What is TB-500 and How does it work?
TB-500 is a synthetic counterpart to Thymosin Beta-4 (Tβ4), a conserved 43-amino acid peptide expressed across multiple tissue types in numerous species. Its biological activity centers on actin binding, through which it facilitates actin polymerization, a process fundamental to cell migration toward injury sites and the formation of new blood vessels. Beyond actin dynamics, TB-500 regulates gene expression across inflammation, wound healing, and tissue remodeling pathways, including upregulation of matrix metalloproteinases (MMPs) that govern extracellular matrix restructuring.
3. Research Findings
- Wound Healing: Enhanced keratinocyte and fibroblast migration, angiogenesis stimulation, and inflammatory attenuation have been documented across multiple wound models, collectively accelerating tissue closure and recovery.
- Anti-Inflammatory Effects: Evidence from various inflammatory models demonstrates TB-500's capacity to suppress pro-inflammatory cytokine production while simultaneously elevating anti-inflammatory cytokine levels.
- Hair Growth Stimulation: Mammalian studies report increases in hair follicle size and facilitation of the telogen-to-anagen phase transition, indicating a role in follicular biology.
- Neuroprotection: Neuroinflammation reduction, oxidative stress attenuation, and decreased apoptotic activity have been observed in preclinical neurological disorder models.
- Cardioprotection: Myocardial infarction models have demonstrated reduced infarct size, improved cardiac function, and enhanced angiogenic activity following TB-500 application.
4. Side Effects
Reported adverse effects include injection site reactions such as pain, redness, and swelling, alongside headache, nausea, dizziness, and fatigue.
5. Summary
Few research peptides engage as broad a spectrum of biological systems as TB-500. Its actin-based mechanism cascades into downstream effects spanning vascular development, immune regulation, neurological resilience, and cardiac protection. As an investigative tool, it offers researchers a multifaceted platform for studying tissue repair and regenerative processes, with findings that may inform future therapeutic development across dermatological, neurological, and cardiovascular disciplines.
6. References
- 1. Bubb MR. Thymosin beta 4 interactions. Vitamins and Hormones, 2003. PubMed 12852258
- 2. Sosne G. Thymosin beta 4 and the eye: the journey from bench to bedside. Expert Opinion on Biological Therapy, 2018. PubMed 30063853
- 3. Pipes GT, Yang J. Cardioprotection by Thymosin Beta 4. Vitamins and Hormones, 2016. PubMed 27450736
- 4. Song K et al. Thymosin beta 4 attenuates PrP(106-126)-induced human brain endothelial cell dysfunction. European Journal of Pharmacology, 2020. PubMed 31877278
- 5. Choi J et al. Thymosin Beta 4 Inhibits LPS and ATP-Induced Hepatic Stellate Cells via Multiple Signaling Pathways. International Journal of Molecular Sciences, 2023. PubMed 36834849
- 6. Kim J, Jung Y. Thymosin Beta 4 Is a Potential Regulator of Hepatic Stellate Cells. Vitamins and Hormones, 2016. PubMed 27450733
- 7. Han HJ et al. Thymosin beta 4-Induced Autophagy Increases Cholinergic Signaling in PrP(106-126)-Treated HT22 Cells. Neurotoxicity Research, 2019. PubMed 30552633
- 8. Kim J, Jung Y. Potential role of thymosin Beta 4 in liver fibrosis. International Journal of Molecular Sciences, 2015. PubMed 26006229
7. Research use
All products on this site are intended exclusively for research and development use. Products are not for human or animal consumption of any kind.
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